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A compound extracted from the legs of centipedes could one day become a potent pain reliever , new research in mice suggests .
" The molecule we discovered was at least as good as , and sometimes significantly honest than morphine , " said study co - author Glenn King , a biochemist at the University of Queensland in Australia .
Centipede stings can be incredibly painful.
And unlike morphia or other painkillers , the centipedevenomcompound did n’t seem to have side effect on the mice , or tend to create permissiveness or addiction , King pronounce .
Painful sting
With each nasty sting , centipedes bring forth just a few microliters of venom , which they let go of from their front pair of wooden leg . Most people who ’ve been bitten say it is excruciatingly painful .
But many venom have intriguing physiological effects , so King and his confrere have spent hour milking the malice of Chinese crimson - headed centipedes , and analyzing the hundreds of compounds in the message to look for promise drug campaigner .
" They ’re nasty little buggers to stress to milk because they ’re so wiggly , " King say LiveScience . " If you do n’t hold them down right , they can just twist around and bite you . "
particular compound
One of the compounds in the spite seemed to block a specific sodium distribution channel in cells , the investigator find oneself . Centipedes likelyevolved this venom moleculeto putting to death insects , but in human being , this distribution channel works by translating atrocious sensations to a feeling of pain sensation in the brain . [ 10 Things You Did n’t Know About the Brain ]
Some people are bear with transmissible mutation that return the channel nonfunctional . Those with this mutationfeel no nuisance and ca n’t sense anything , but are otherwise perfectly healthy .
To test the compound , the team gave it to shiner , then subjugate the animals to pain from several generator , such as acid and heat . Mice pass on the compound have much less painfulness than control black eye , and the drug ’s pain relief was tantamount to that of opioids , the investigator found .
In addition , the team detected no side effects . Because citizenry who miss this distribution channel are healthy , the researchers said they wait that side force of the compound in humankind should also be minimum .
The findings hint the novel chemical compound could be useful for treatingchronic painand other types of recalcitrant pain , King say .
Limited options
Opioids , the current first - line options for many types of pain , often do n’t influence for the great unwashed with certain types of bother , and cell lay off responding to the drug over prison term . That requires people to take big and larger doses to get the same effects . In addition , opioids stop up into the trunk ’s born reward system , which creates a high and makes the medicines potentially habit-forming .
By line , this newly discovered molecule does n’t tap into the body ’s tone - honorable system , elude the electric potential for addiction . The research worker said they also distrust that the compound will not produce the same tolerance effects over time .
Still , study in humans are needed to determine if the compound works in people , and if it is safe . The squad is also consider several other spite compounds that stymy the same duct , so it may be that another compound proves more effective in the long run , King said .
The determination was detailed Sept. 30 in the journal Proceedings of the National Academy of Sciences .
